Anti-MELK

Anti-MELK
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-F50147-0.08ML 80 µl - -

3 - 10 Werktage*

326,00 €
NSJ-F50147-0.4ML 400 µl - -

3 - 10 Werktage*

702,00 €
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. MELK Contains 1 protein kinase domain that Belongs to... mehr
Produktinformationen "Anti-MELK"
In 1X PBS, pH 7.4, with 0.09% sodium azide. MELK Contains 1 protein kinase domain that Belongs to the Ser/Thr protein kinase family. It phosphorylates ZNF622 and may contribute to its redirection to the nucleus. MELK may also be involved in the inhibition of spliceosome assembly during mitosis. Protein function: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. [The UniProt Consortium]
Schlagworte: Anti-MELK, Anti-hPK38, Anti-hMELK, Anti-KIAA0175, EC=2.7.11.1, EC=2.7.10.2, Anti-pEg3 kinase, Anti-Protein kinase Eg3, Anti-Protein kinase PK38, Anti-Tyrosine-protein kinase MELK, Anti-Maternal embryonic leucine zipper kinase, MELK Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: F50147

Eigenschaften

Anwendung: WB, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: A portion of amino acids 525-554 from the human protein was used as the immunogen for this MELK antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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