Anti-MEKK4, ID (C1081) (MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1, Mitogen-activated protein kinase kin

Anti-MEKK4, ID (C1081) (MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1, Mitogen-activated protein kinase kin
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
038350-Biotin.200 200 µl - -

3 - 19 Werktage*

790,00 €
 
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade... mehr
Produktinformationen "Anti-MEKK4, ID (C1081) (MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1, Mitogen-activated protein kinase kin"
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. Applications: Suitable for use in Western Blot, Immunohistochemistry, ELISA, Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-500, Immunohistochemistry: 1:10-50, Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Schlagworte: Anti-MEKK 4, Anti-MAP3K4, Anti-KIAA0213, Anti-MEK kinase 4, EC=2.7.11.25, Anti-MAP three kinase 1, Anti-MAPK/ERK kinase kinase 4, Anti-Mitogen-activated protein kinase kinase kinase 4
Hersteller: United States Biological
Hersteller-Nr: 038350-Biotin

Eigenschaften

Anwendung: ELISA, IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: Biotin
Wirt: Rabbit
Reaktivität: Human
Immunogen: MEKK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1065-1097 amino acids from the Central region of human MEKK4.
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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