Anti-MDC1, clone P2B11

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG22275.50 50 µg - -

6 - 14 Werktage

439,00 €
 
Protein function: Required for checkpoint mediated cell cycle arrest in response to DNA damage... mehr
Produktinformationen "Anti-MDC1, clone P2B11"
Protein function: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. [The UniProt Consortium]
Schlagworte: Anti-Mdc1, Anti-Kiaa0170, Anti-Mediator of DNA damage checkpoint protein 1
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG22275050

Eigenschaften

Anwendung: WB, ICC, IF
Antikörper-Typ: Monoclonal
Klon: P2B11
Konjugat: No
Wirt: Mouse
Reaktivität: Human, Mouse, Bovine, Chimpanzee
Immunogen: GST-tagged recombinant protein around the N-terminus of Mouse MDC1
MW: 184 kD
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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