Anti-MAP1ALC3, cleaved (LC3B, MAP1A/1BLC3, MAP1LC3B) (Azide free) (APC)

Anti-MAP1ALC3, cleaved (LC3B, MAP1A/1BLC3, MAP1LC3B) (Azide free) (APC)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
038092-APC.200 200 µl - -

3 - 19 Werktage*

993,00 €
 
Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic... mehr
Produktinformationen "Anti-MAP1ALC3, cleaved (LC3B, MAP1A/1BLC3, MAP1LC3B) (Azide free) (APC)"
Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3b is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. Applications: Suitable for use in Western Blot, Immunohistochemistry, FLISA, Recommended Dilution: FLISA: 1:1,000, Western blot 1:100-500, Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Hersteller: United States Biological
Hersteller-Nr: 038092-APC

Eigenschaften

Anwendung: FLISA, IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: APC
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Cleaved LC3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96~125 amino acids from the C-terminal region of human Cleaved MAP1LC3B.
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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