Anti-Lipin 1 (LPIN1, DKFZp781P1796, KIAA0188)

Anti-Lipin 1 (LPIN1, DKFZp781P1796, KIAA0188)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
L2497-01E.100 100 µl - -

3 - 19 Werktage*

498,00 €
 
The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of... mehr
Produktinformationen "Anti-Lipin 1 (LPIN1, DKFZp781P1796, KIAA0188)"
The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1&,#225, target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPAR&,#225,. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance. Cellular Localization: Nuclear , Positive Control: 3T3-L1 cell lysates. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Hersteller: United States Biological
Hersteller-Nr: L2497-01E

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse
Immunogen: A synthetic peptide to an internal region (within residues 300-400) of the human LPIN1 protein. [Swiss-Prot# Q14693]. Homology: 100% homology with human protein, 95% with mouse protein, and 90% with rat protein.
Reinheit: Purified by peptide immunoaffinity chromatography.
Format: Affinity Purified

Datenbank Information

Handhabung & Sicherheit

Lagerung: -20°C (-20°C Glycerol)
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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