Anti-LBR / Lamin B Receptor

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-RQ5307 100 µg - -

3 - 10 Werktage*

755,00 €
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Lamin-B receptor is a protein, and in... mehr
Produktinformationen "Anti-LBR / Lamin B Receptor"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Lamin-B receptor is a protein, and in humans, it is encoded by the LBR gene. It is mapped to 1q42.12. The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. Protein function: Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:9630650, PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation. Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation. Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). [The UniProt Consortium]
Schlagworte: Anti-LBR, Anti-C14SR, Anti-LMN2R, Anti-Delta-14-SR, Anti-Lamin-B receptor, Anti-Sterol C14-reductase, Anti-C-14 sterol reductase, Anti-Delta(14)-sterol reductase LBR, Anti-3-beta-hydroxysterol Delta (14)-reductase, LBR Antibody / Lamin B Receptor
Hersteller: NSJ Bioreagents
Hersteller-Nr: RQ5307

Eigenschaften

Anwendung: WB, IHC (paraffin), IF, FC, Direct ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: Amino acids H102-F209 from the human protein
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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