Anti-LANA 2 (Latency-Associated Nuclear Antigen 2, LANA-2)

LANA2 (latency-associated nuclear antigen) is an inhibitor of p53-induced transcription in reporter assays and may be an apoptosis antagonist. It is a nuclear protein associated with Kaposi's sarcoma-associated herpes virus (KSHV), or human herpes virus 8. It is found in abundance in the nuclei of cultured cells from KSHV-infected hematopoietic tissues, such as PEL (primary effusion lymphoma) and CD (multicentric Castleman's disease). It does not appear to be expressed in KS (Kaposi's sarcoma) lesions. Applications: Suitable for use in ELISA, Immunohistochemistry, Immunofluorescence, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Frozen and paraffin): 1:10-1:2000, ELISA: 1:100-1:2000, Immunofluorescence (IC): 1:10-1:2000, Western Blot: 2-4ug/ml detects a band at ~66-70kD., Immunoprecipitation: 1:10-1:500, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.