Anti-LAMB1, CT (LAMB1, Laminin subunit beta-1, Laminin B1 chain, Laminin-1 subunit beta, Laminin-10

Anti-LAMB1, CT (LAMB1, Laminin subunit beta-1, Laminin B1 chain, Laminin-1 subunit beta, Laminin-10
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
037665-Biotin.200 200 µl - -

3 - 19 Werktage*

993,00 €
 
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous... mehr
Produktinformationen "Anti-LAMB1, CT (LAMB1, Laminin subunit beta-1, Laminin B1 chain, Laminin-1 subunit beta, Laminin-10"
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. Applications: Suitable for use in Western Blot, Immunohistochemistry, ELISA, Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-500, Immunohistochemistry: 1:10-50, Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Schlagworte: Anti-LAMB1, Anti-Laminin B1 chain, Anti-Laminin-2 subunit beta, Anti-Laminin-8 subunit beta, Anti-Laminin-6 subunit beta, Anti-Laminin subunit beta-1, Anti-Laminin-1 subunit beta, Anti-Laminin-10 subunit beta, Anti-Laminin-12 subunit beta
Hersteller: United States Biological
Hersteller-Nr: 037665-Biotin

Eigenschaften

Anwendung: ELISA, IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: Biotin
Wirt: Rabbit
Spezies-Reaktivität: human, mouse
Immunogen: LAMB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1690-1720 amino acids from the C-terminal region of human LAMB1.
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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