Anti-Interleukin-13 (IL-13)

Anti-Interleukin-13 (IL-13)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
200-401-B55 100 µg - -

1 - 9 Werktage

471,00 €
Interleukin 13 (IL-13), of the IL-4 superfamily, is a cytokine secreted by many cell types, but... mehr
Produktinformationen "Anti-Interleukin-13 (IL-13)"
Interleukin 13 (IL-13), of the IL-4 superfamily, is a cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells, that is an important mediator of allergic inflammation and disease. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Ra) and at least one IL-13-specific binding chain. Most of the biological effects of IL-13, like those of IL-4, are linked to a single transcription factor, STAT6. In humans, IL-13 can induce immunoglobulin E (IgE) secretion from activated B cells. In mice, deletion of IL-13 does not markedly affect either Th2 cell development or antigen-specific IgE responses induced by potent allergens. Deletion of IL-4 abrogates these responses. IL-13 acts as a molecular bridge linking allergic inflammatory cells to the non-immune cells in contact with them, thus altering physiological function. Although IL-13 is associated primarily with the induction of airway disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, it also induces airway matrix metalloproteinases as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation.
Schlagworte: Anti-IL13, Anti-IL-13, Anti-Interleukin-13
Hersteller: Rockland Immunochemicals
Hersteller-Nr: 200-401-B55


Anwendung: WB, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Swine, Sheep, Bovine
Immunogen: full length recombinant protein raised in yeast, corresponding to mature swine IL-13 protein
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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