Anti-Insulin (Clone: BS22)

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-10-12510-500 500 µl -

3 - 11 Werktage*

1.154,00 €
 
Protein function: Key downstream component of the canonical Wnt signaling pathway. In the absence... mehr
Produktinformationen "Anti-Insulin (Clone: BS22)"
Protein function: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E- cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (PubMed:21325504). [The UniProt Consortium]
Schlagworte: Anti-Catnb, Anti-Ctnnb1, Anti-Beta-catenin, Anti-Catenin beta-1, Mouse Monoclonal Antibody to Insulin(Clone :BS22)
Hersteller: Abeomics
Hersteller-Nr: 10-12510

Eigenschaften

Anwendung: IHC
Antikörper-Typ: Monoclonal
Klon: BS22
Konjugat: No
Wirt: Mouse
Reaktivität: Human

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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