Anti-IL4I1, clone CL9071

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ATA-AMAb91560.25 25 µl -

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156,00 €
ATA-AMAb91560.100 100 µl -

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363,00 €
 
Protein function: Secreted L-amino-acid oxidase that acts as a key immunoregulator... mehr
Produktinformationen "Anti-IL4I1, clone CL9071"
Protein function: Secreted L-amino-acid oxidase that acts as a key immunoregulator (PubMed:17356132, PubMed:32818467, PubMed:32866000). Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively (PubMed:17356132, PubMed:32818467, PubMed:32866000). Also has weak L-arginine oxidase activity (PubMed:26673964). Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR (PubMed:32818467, PubMed:32866000). IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer (PubMed:32818467, PubMed:32866000). AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Also has an immunoregulatory function in some immune cells, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4(+) T-cells into FOXP3(+) regulatory T- cells (Treg) and regulates the development and function of B-cells (PubMed:17356132, PubMed:25446972, PubMed:25778793, PubMed:28891065). Also regulates M2 macrophage polarization by inhibiting T-cell activation. Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4(+) and H2O2 (PubMed:23355881). [The UniProt Consortium] Validated by orthogonal and standard strategies. Buffer: The antibodies are delivered in 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Schlagworte: Anti-LAO, Anti-LAAO, Anti-hFIG1, Anti-hIL4I1, Anti-Protein Fig-1, Anti-L-amino-acid oxidase, Anti-IL4-induced protein 1, Anti-Interleukin-4-induced protein 1
Hersteller: Atlas Antibodies
Hersteller-Nr: AMAb91560

Eigenschaften

Anwendung: WB, IHC
Antikörper-Typ: Monoclonal
Klon: CL9071
Konjugat: No
Wirt: Mouse
Reaktivität: Human
Immunogen: Synthetic Peptide: SFRRPFWREE HIEGGHSNTD RPSR

Datenbank Information

KEGG ID : K03334 | Passende Produkte
UniProt ID : Q96RQ9 | Passende Produkte
Gene ID : GeneID 259307 | Passende Produkte
Protein Atlas Nr. : ENSG00000104951

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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