Anti-IL-10RA / IL-10R1, clone 1B1.3a

Anti-IL-10RA / IL-10R1, clone 1B1.3a
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-V8346-20UG 20 µg - -

3 - 10 Werktage*

332,00 €
NSJ-V8346-100UG 100 µg - -

3 - 10 Werktage*

752,00 €
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This monoclonal antibody... mehr
Produktinformationen "Anti-IL-10RA / IL-10R1, clone 1B1.3a"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This monoclonal antibody recognizes Mouse Interleukin-10 receptor 1 (IL-10R1), a cell surface glycoprotein of approximately 110KDa. Its epitope is localized in the ligand-binding domain in the extracellular region of Mouse IL-10R1. This antibody blocks the binding of IL-10 to its receptor. IL-10R1 is a class II cytokine receptor expressed on thymocytes, T cells, B cells, NK cells, monocytes and macrophages. Binding of IL-10 to its receptor initiates JAK/STAT signaling that leads to B cell proliferation and inhibition of macrophage activation. Protein function: Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3 (PubMed:8910398). Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy. [The UniProt Consortium]
Schlagworte: Anti-CD210, Anti-Il10r, Anti-Il10ra, Anti-IL-10RA, Anti-IL-10R1, Anti-CDw210a, Anti-IL-10R subunit 1, Anti-IL-10R subunit alpha, Anti-IL-10 receptor subunit alpha, Anti-Interleukin-10 receptor subunit 1, Anti-Interleukin-10 receptor subunit alpha, IL-10RA
Hersteller: NSJ Bioreagents
Hersteller-Nr: V8346

Eigenschaften

Anwendung: FC
Antikörper-Typ: Monoclonal
Klon: 1B1.3a
Konjugat: No
Wirt: Rat
Spezies-Reaktivität: mouse
Immunogen: Purified recombinant extracellular region of mouse IL10RA
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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