Anti-IkBa

0.5mg/ml if reconstituted with 0.2ml sterile DI water. NFKBIA, also called IkBa or MAD-3, is one member of a family of cellular proteins that function to inhibit the NF-kB transcription factor. It inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. It moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. The effect of the nonpathogenic bacteria is specific to the SCF complex substrates beta Catenin and IkBa. This may help to explain the beneficial effects of treatment of inflammatory bowel disease with nonpathogenic probiotic enteric organisms. In addition, IkBa blocks the ability of NFkB transcription factors to bind to DNA, which is required for proper NFkB functioning. Protein function: Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. [The UniProt Consortium]