Anti-Human CD180 (Clone-MHR73)

Anti-Human CD180 (Clone-MHR73)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-10-3513-100 100 µg -

3 - 11 Werktage*

2.558,00 €
ABE-10-3513-500 500 µg -

3 - 11 Werktage*

2.558,00 €
 
The monoclonal antibody 10-3513 reacts with human RP105 (CD180). RP105 is a type 1 transmembrane... mehr
Produktinformationen "Anti-Human CD180 (Clone-MHR73)"
The monoclonal antibody 10-3513 reacts with human RP105 (CD180). RP105 is a type 1 transmembrane protein of 105 kDa with extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. RP105 expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (MHR73) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule CD80, revealing RP105 as a potent regulator of B-cell activation. In this context it is important to note that RP105 is associated with MD1, and that it mediates B-cell surface expression and LPS recognition and signalling in cooperation with TLR4. MD-1 seems to be requisite for efficient expression of RP105. Protein function: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells. [The UniProt Consortium]
Schlagworte: Anti-LY64, Anti-CD180, Anti-CD180 antigen, Anti-Lymphocyte antigen 64, Anti-Radioprotective 105 kDa protein, Monoclonal Antibody to Human CD180 (Clone-MHR73)
Hersteller: Abeomics
Hersteller-Nr: 10-3513

Eigenschaften

Anwendung: FC, FA, IP, IHC
Antikörper-Typ: Monoclonal
Klon: MHR73
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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