Anti-HSPA5

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA038846.100 100 µl -

7 - 10 Werktage*

358,00 €
 
Protein function: Endoplasmic reticulum chaperone that plays a key role in protein folding and... mehr
Produktinformationen "Anti-HSPA5"
Protein function: Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate. Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1. Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 99% and to rat: 99%
Schlagworte: Anti-BiP, Anti-GRP-78, Anti-HSP70 family protein 5, Anti-Binding-immunoglobulin protein, Anti-78 kDa glucose-regulated protein, Anti-Endoplasmic reticulum chaperone BiP, Anti-Heat shock protein family A member 5
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA038846

Eigenschaften

Anwendung: IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: GEDFDQRVME HFIKLYKKKT GKDVRKDNRA VQKLRREVEK AKRALSSQHQ ARIEIESFYE GEDFSETLTR AK (ATA-APrEST81776)

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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