Anti-Hrs, clone 19-5

Anti-Hrs, clone 19-5
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
MM-0061-P 50 µg - -

3 - 8 Werktage*

488,00 €
 
Protein function: Involved in intracellular signal transduction mediated by cytokines and growth... mehr
Produktinformationen "Anti-Hrs, clone 19-5"
Protein function: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. [The UniProt Consortium]
Schlagworte: Anti-Hrs, Anti-HRS, Anti-HGS, Anti-Protein pp110, Anti-Hepatocyte growth factor-regulated tyrosine kinase substrate
Hersteller: MediMabs
Hersteller-Nr: MM-0061-P

Eigenschaften

Anwendung: WB, IHC, IP
Antikörper-Typ: Monoclonal
Klon: 19-5
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human, rat, mouse, monkey
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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