Anti-HNRNPA2B1

Anti-HNRNPA2B1
Anti-HNRNPA2B1
   
NEU
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ATA-HPA005812.100 100 µl -

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363,00 €
 
Protein function: Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent... mehr
Produktinformationen "Anti-HNRNPA2B1"
Protein function: Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion. Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays also a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 100% and to rat: 100%
Schlagworte: Anti-HNRPA2B1, Anti-HNRNPA2B1, Anti-hnRNP A2/B1, Anti-Heterogeneous nuclear ribonucleoproteins A2/B1
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA005812

Eigenschaften

Anwendung: ICC, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: VMRDPASKRS RGFGFVTFSS MAEVDAAMAA RPHSIDGRVV EPKRAVAREE SGKPGAHVTV KKLFVGGIKE DTEEHHLRDY FEEYGKIDTI EIITDRQSGK KRGFGFVTFD DHDPVDKIVL QKYHTINGHN AEVRKAL (ATA-APrEST77474)

Datenbank Information

KEGG ID : K13158 | Passende Produkte
UniProt ID : P22626 | Passende Produkte
Gene ID : GeneID 3181 | Passende Produkte
Protein Atlas Nr. : ENSG00000122566

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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