Anti-Histone H3.3 G34W Mutant (human), Rabbit Monoclonal (RM263)

Anti-Histone H3.3 G34W Mutant (human), Rabbit Monoclonal (RM263)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
REV-31-1145-00-R100 100 µl - -

3 - 9 Werktage*

483,00 €
REV-31-1145-00-R400 400 µl - -

3 - 9 Werktage*

1.175,00 €
 
Recombinant Antibody. This antibody reacts to the Histone H3.3 G34W mutant. No cross reactivity... mehr
Produktinformationen "Anti-Histone H3.3 G34W Mutant (human), Rabbit Monoclonal (RM263)"
Recombinant Antibody. This antibody reacts to the Histone H3.3 G34W mutant. No cross reactivity with wild type Histone H3.3. Applications: WB, ELISA, IHC, ICC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Histone H3 has three main variants, H3.1 and H3.2, which are deposited in chromatin only during DNA replication and H3.3, which is replication independent and is found primarily in the regions of active transcription and heterochromatin. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. Histone modifications are one form of epigenetic information that relate closely to gene regulation. Aberrant histone methylation caused by alteration in chromatin-modifying enzymes has long been implicated in cancers. Recently, recurrent histone mutations have been identified in multiple cancers and have been shown to impede histone methylation. All identified histone mutations (including H3K4M, H3K9M, H3K27M, H3K36M, and H3G34V/R/W) result in amino acid substitution at/near a lysine residue that is a target of methylation.
Schlagworte: H3.3 G34W
Hersteller: RevMAb Biosciences
Hersteller-Nr: 31-1145-00

Eigenschaften

Anwendung: WB, ELISA, IHC, ICC
Antikörper-Typ: Monoclonal
Klon: RM263
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-Histone H3.3 G34W Mutant (human), Rabbit Monoclonal (RM263)"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen