Anti-Histone H2A.X

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-63536.60 60 µl - -

7 - 16 Werktage*

117,00 €
E-AB-63536.120 120 µl - -

7 - 16 Werktage*

208,00 €
E-AB-63536.200 200 µl - -

7 - 16 Werktage*

363,00 €
 
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the... mehr
Produktinformationen "Anti-Histone H2A.X"
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. Protein function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation. [The UniProt Consortium]
Schlagworte: Anti-H2AX, Anti-H2AFX, Anti-H2a/x, Anti-Histone H2AX, Anti-Histone H2A.X, Histone H2A.X Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-63536

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse, Rat
Immunogen: A synthetic peptide of human H2AFX

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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