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Anti-Her2/Neu Monoclonal Antibody (Clone:IHC002)-Ready to Use

Anti-Her2/Neu Monoclonal Antibody (Clone:IHC002)-Ready to Use
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-44-1035-7 7 ml -

2 - 11 Werktage

666,00 €
 
The Her2/Neu (c-erbB-2) proto-oncogene is a transmembrane receptor tyrosine kinase that is... mehr
Produktinformationen "Anti-Her2/Neu Monoclonal Antibody (Clone:IHC002)-Ready to Use"
The Her2/Neu (c-erbB-2) proto-oncogene is a transmembrane receptor tyrosine kinase that is clinically indicated in a number of carcinomas. Overexpression of the c-erbB-2 protein has been associated with ductal breast cancer, as well as pulmonary and gastric adenocarcinomas. A correlation between Her2 and p53 has also been documented, as overexpression of both proteins has been associated with early invasion and metastasis in bladder cancer. Protein function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. [The UniProt Consortium]
Schlagworte: Anti-HER2, Anti-ERBB2, Anti-CD340, Anti-MLN 19, Anti-p185erbB2, EC=2.7.10.1, Anti-Proto-oncogene Neu, Anti-Proto-oncogene c-ErbB-2, Anti-Metastatic lymph node gene 19 protein, Anti-Receptor tyrosine-protein kinase erbB-2, Anti-Her2/Neu Monoclonal Antibody
Hersteller: Abeomics
Hersteller-Nr: 44-1035-7

Eigenschaften

Anwendung: ELISA, IHC
Antikörper-Typ: Monoclonal
Klon: IHC002
Konjugat: No
Wirt: Mouse
Reaktivität: Human
Immunogen: Recombinant Human Her2/Neu

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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