Anti-HER2, clone CL0268

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-AMAb90627.25 25 µl -

7 - 10 Werktage*

240,00 €
ATA-AMAb90627.100 100 µl -

7 - 10 Werktage*

358,00 €
 
Protein function: Protein tyrosine kinase that is part of several cell surface receptor... mehr
Produktinformationen "Anti-HER2, clone CL0268"
Protein function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. [The UniProt Consortium] Validated by standard strategies. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 84% and to rat: 85%. Epitope specificity: ARVCYGLGME.
Schlagworte: Anti-HER2, Anti-CD340, Anti-ERBB2, Anti-MLN 19, Anti-p185erbB2, EC=2.7.10.1, Anti-Proto-oncogene Neu, Anti-Proto-oncogene c-ErbB-2, Anti-Metastatic lymph node gene 19 protein, Anti-Receptor tyrosine-protein kinase erbB-2
Hersteller: Atlas Antibodies
Hersteller-Nr: AMAb90627

Eigenschaften

Anwendung: IHC, WB
Antikörper-Typ: Monoclonal
Klon: CL0268
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: YNTDTFESMP NPEGRYTFGA SCVTACPYNY LSTDVGSCTL VCPLHNQEVT AEDGTQRCEK CSKPCARVCY GLGMEHLREV RAVTSANIQE FAGCKKIFGS LAFLPESFDG DPASNTAPLQ PEQLQVFGAP HR (ATA-APrEST93786)

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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