Anti-GRP78 (Clone 7D8)

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay25690-100 100 µg -

6 - 10 Werktage*

329,00 €
Glucose-regulated protein 78 kDa (GRP78), also known as heat shock 70 kDa protein 5 (HspA5) and... mehr
Produktinformationen "Anti-GRP78 (Clone 7D8)"
Glucose-regulated protein 78 kDa (GRP78), also known as heat shock 70 kDa protein 5 (HspA5) and immunoglobulin heavy chain-binding protein (BiP), is a glucose-regulated protein that is constitutively expressed in the lumen of the endoplasmic reticulum (ER). It is composed of two functional domains, an N-terminal nucleotide-binding domain that contains an ATP catalytic site and a C-terminal substrate binding domain that binds hydrophobic polypeptides. GRP78 functions as a molecular chaperone, assisting in the translocation of polypeptides from the cytosol into the ER, folding of nascent polypeptides, as well as refolding and preventing aggregation of misfolded proteins. It also plays a role in the ER-assisted degradation (ERAD) and unfolded protein response (UPR) pathways. GRP78 chaperone activity is driven by an ATPase cycle that is regulated by ER-localized DnaJ-like protein co-factors and nuclear exchange factors. Expression of GRP78 is upregulated in response to ER stress caused by viral and bacterial infections as well as various cancers. ER stress can also promote extracellular secretion of GRP78 leading to its anti-inflammatory functions in immunity. Cayman's GRP78 Monoclonal Antibody can be used for Western blot and ELISA applications. The antibody recognizes GRP78 at ~72 kDa from human, mouse, and rat samples. Synonyms: Binding-immunoglobulin Protein, BiP, Endoplasmic Reticulum Chaperone BiP, 78 kDa Glucose-regulated Protein, Heat Shock Protein Family A Member 5, Heat Shock Protein 70 Family Protein 5, Hsp70 Family Protein 5, Immunoglobulin Heavy Chain-binding Protein. Immunogen: Full length human recombinant GRP78 protein. Clone Designation: 7D8. Formulation: 100 µg of protein G-purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: ELISA, IHC, and WB. Cross Reactivity: (-) Hsp70. UniProt Accession #: P11021.
Schlagworte: Anti-BiP {ECO:0000303|Ref.4}, Anti-BiP {ECO:0000303|Ref.4}, Anti-GRP-78 {ECO:0000303|PubMed:2840249}, Anti-GRP-78 {ECO:0000303|PubMed:2840249}, Anti-HSP70 family protein 5 {ECO:0000305}, Anti-HSP70 family protein 5 {ECO:0000305}, Anti-Endoplasmic reticulu
Hersteller: Cayman Chemical
Hersteller-Nr: 25690


Anwendung: ELISA, IHC, WB
Antikörper-Typ: Monoclonal
Klon: 7D8
Konjugat: No
Wirt: Mouse
Reaktivität: Human, Mouse, Rat
Immunogen: Full length human recombinant GRP78 protein
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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