Anti-GRN, clone CL5692

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-AMAb91384.25 25 µl -

7 - 10 Werktage*

300,00 €
ATA-AMAb91384.100 100 µl -

7 - 10 Werktage*

421,00 €
 
Protein function: Secreted protein that acts as a key regulator of lysosomal function and as a... mehr
Produktinformationen "Anti-GRN, clone CL5692"
Protein function: Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:28541286, PubMed:28073925, PubMed:18378771, PubMed:28453791, PubMed:12526812). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:18378771). [The UniProt Consortium] Validated by standard strategies. Buffer: The antibodies are delivered in 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 72% and to rat: 76%
Hersteller: Atlas Antibodies
Hersteller-Nr: AMAb91384

Eigenschaften

Anwendung: IHC
Antikörper-Typ: Monoclonal
Klon: CL5692
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: SCPDGYTCCR LQSGAWGCCP FTQAVCCEDH IHCCPAGFTC DTQKGTCEQG PHQVPWMEKA PAHLSLPDPQ ALKRDVPCDN VSSCPSSDTC CQLTSGEWGC CPIPEAVCCS DHQHCCPQGY TCVAEGQCQR GSEIVAGL (ATA-APrEST86779)

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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