Anti-GAPDH

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A303-878A-T 10 µl (10 µg) -

2 - 8 Werktage*

164,00 €
A303-878A 100 µl (100 µg) -

2 - 8 Werktage*

588,00 €
 
Protein function: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities,... mehr
Produktinformationen "Anti-GAPDH"
Protein function: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D- glyceroyl phosphate. Component of the GAIT (gamma interferon- activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. [The UniProt Consortium]
Schlagworte: Anti-GAPD, Anti-GAPDH, Anti-CDABP0047, EC=1.2.1.12, EC=2.6.99.-, Anti-Peptidyl-cysteine S-nitrosylase GAPDH, Anti-Glyceraldehyde-3-phosphate dehydrogenase
Hersteller: Bethyl Laboratories
Hersteller-Nr: A303-878A

Eigenschaften

Anwendung: WB, IP, IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Goat
Spezies-Reaktivität: human, mouse (Erwartet: rat, D. melanogaster, zebrafish, X. laevis, chicken, sheep, bovine, rabbit, guinea pig_10141, pig, golden hamster, cat)
Immunogen: synthetic peptide. The epitope recognized by A303-878A-T maps to a region between residue 175 and 225 of human Glyceraldehyde-3-Phosphate Dehydrogenase using the numbering given in entry NP_002037.2 (GeneID 2597).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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