Anti-GABAA Receptor delta-subunit (N-Term)

Anti-GABAA Receptor delta-subunit (N-Term)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay10600-1 1 each -

3 - 10 Werktage

432,00 €
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous... mehr
Produktinformationen "Anti-GABAA Receptor delta-subunit (N-Term)"
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alpha's, four beta's, and four gamma's, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, co-expression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. More recently there have been a number of studies demonstrating that the delta-subunit of the receptor may affect subunit assembly and may also confer differential sensitivity to neurosteroids and to ethanol.
Hersteller: Cayman Chemical
Hersteller-Nr: 10600-1


Anwendung: IHC, IP, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Rat
Immunogen: fusion protein from the N-terminus of the delta-subunit of rat GABAA receptor
Format: Solid

Datenbank Information

KEGG ID : K05184 | Finde Alternativen
UniProt ID : P18506 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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