Anti-GABAA Receptor alpha4 Subunit

Anti-GABAA Receptor alpha4 Subunit
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay29270-100 100 µl -

6 - 10 Werktage*

649,00 €
 
GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory... mehr
Produktinformationen "Anti-GABAA Receptor alpha4 Subunit"
GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS. They are postsynaptic heteropentameric receptors that contains protein subunits from the following isoforms: alpha1-6, beta1-4, gamma1-3, delta, epsilon, pi, theta, and rho1-3, arranged around a central pore. Phasic inhibitory synaptic transmission is regulated by alpha1beta2gamma2 subunit-containing GABAA receptors, the major isoform found in the brain. The alpha subunit of GABAA receptors interfaces with a beta subunit to form the GABA binding site that initiates GABA-induced action potentials and forms the benzodiazepine binding site with the gamma subunit. The GABAA receptor alpha4 subunit is found at high levels in the thalamus and hippocampal dentate gyrus, with moderate levels in the cortex and low levels in other brain regions. Knockdown of Gabrar4, which encodes the alpha4 subunit isoform, inhibits tonic inhibition in thalamic relay neurons and prevents sedative effects induced by the GABAA receptor agonist gaboxadol (Cay-16355) or ethanol in mice. Gabrar4 knockout also inhibits the development of tolerance in a rat model of chronic intermittent ethanol administration. Cayman's GABAA Receptor alpha4 Subunit Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes the GABAA receptor alpha4 subunit at approximately 64 kDa from mouse and rat samples.Synonyms: Gamma-aminobutyric Acid (GABA) A Receptor, alpha4, Gamma-aminobutyric Acid Receptor Subunit alpha4, GABAA Receptor Subunit alpha4. Immunogen: Fusion protein from the cytoplasmic loop of the alpha4 subunit of the rat GABAA receptor. MW: ~64 kDa. Formulation: (Request formulation change), 100 µl of affinity-purified pooled rabbit serum polyclonal antibody. Storage Buffer: 10 mM HEPES, pH 7.5, with 150 mM sodium chloride, 100 µg/ml BSA, and 50% glycerol. Host: Rabbit. Applications: IHC, WB.
Schlagworte: GABAA Receptor Subunit alpha4, Gamma-aminobutyric Acid (GABA) A Receptor, alpha4, Gamma-aminobutyric Acid Receptor Subunit alpha4
Hersteller: Cayman Chemical
Hersteller-Nr: 29270

Eigenschaften

Anwendung: IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: mouse, rat
Immunogen: Fusion protein from the cytoplasmic loop of the ?4 subunit of the rat GABAA receptor
MW: 64 kD
Format: Solid

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-GABAA Receptor alpha4 Subunit"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen