Anti-GABA B Receptor 1, clone S93A-49

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG22243.50 50 µg - -

6 - 14 Werktage

439,00 €
 
Protein function: Component of a heterodimeric G-protein coupled receptor for GABA, formed by... mehr
Produktinformationen "Anti-GABA B Receptor 1, clone S93A-49"
Protein function: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. [The UniProt Consortium]
Schlagworte: Anti-Gb1, Anti-Gabbr1, Anti-GABABR1, Anti-GABA-BR1, Anti-GABA-B-R1, Anti-GABA-B receptor 1, Anti-Gamma-aminobutyric acid type B receptor subunit 1
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG22243050

Eigenschaften

Anwendung: WB, ICC, IF
Antikörper-Typ: Monoclonal
Klon: S93A-49
Konjugat: No
Wirt: Mouse
Reaktivität: Human, Mouse, Rat
Immunogen: Fusion protein around aa. 873-977 (cytoplasmic C-terminus) of Rat GABA B Receptor 1
MW: 115 kD
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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