Anti-GAB1

Anti-GAB1
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Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
200-401-G66 100 µg - -

1 - 9 Werktage

493,00 €
 
Anti-GAB1 antibody is directed against human GAB1. The antibody detects both unphosphorylated and... mehr
Produktinformationen "Anti-GAB1"
Anti-GAB1 antibody is directed against human GAB1. The antibody detects both unphosphorylated and phosphorylated forms of the protein. Anti-GAB1 antibody was purified from rabbit serum by Protein A chromatography followed by cross adsoption. Cross reactivity with GAB1 from other species has not been determined. GAB1 antibody detects GAB1 which is a member of the IRS1-like multisubstrate docking protein family. The protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. GAB1 plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. It is known to play a role in FGFR1 signaling and is probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). GAB1 interacts with GRB2 and with other SH2-containing proteins. It is known to interact with phosphorylated LAT2, PTPRJ, FRS2, GRB2, PIK3R1 and SOS1. GAB1 gets phosphorylated in response to FGFR1 activation. This tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Anti-GAB1 Antibody is ideal for investigators involved in Cell Signaling, Cancer, Neuroscience and Signal Transduction research.
Schlagworte: Anti-GAB1, Anti-GRB2-associated binder 1, Anti-GRB2-associated-binding protein 1, Anti-Growth factor receptor bound protein 2-associated protein 1
Hersteller: Rockland Immunochemicals
Hersteller-Nr: 200-401-G66

Eigenschaften

Anwendung: ELISA, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human
Immunogen: recombinant protein produced in Sf9 cells corresponding to the full length human GAB protein.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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