Anti-Fyn, clone 4B8-E7-A8

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG54079.50 50 µl - -

6 - 14 Werktage*

436,00 €
ARG54079.100 100 µl - -

6 - 14 Werktage*

624,00 €
 
Protein function: Non-receptor tyrosine-protein kinase that plays a role in many biological... mehr
Produktinformationen "Anti-Fyn, clone 4B8-E7-A8"
Protein function: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta- catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. [The UniProt Consortium]
Schlagworte: Anti-FYN, Anti-SLK, Anti-p59-Fyn, EC=2.7.10.2, Anti-Src-like kinase, Anti-Proto-oncogene Syn, Anti-Proto-oncogene c-Fyn, Anti-Tyrosine-protein kinase Fyn
Hersteller: Arigo Biolaboratories
Hersteller-Nr: ARG54079

Eigenschaften

Anwendung: WB, ICC, IF
Antikörper-Typ: Monoclonal
Klon: 4B8-E7-A8
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human, monkey, rat, mouse
Immunogen: Purified recombinant human Fyn protein fragments expressed in E.coli
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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