Anti-Frataxin / FXN, clone FDAX-1

Anti-Frataxin / FXN, clone FDAX-1
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-V3997SAF-100UG 100 µg - -

3 - 10 Werktage*

752,00 €
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. Reduced expression of frataxin is the cause of... mehr
Produktinformationen "Anti-Frataxin / FXN, clone FDAX-1"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Reduced expression of frataxin is the cause of Friedreich's ataxia (FRDA), a lethal neurodegenerative disease. The reduction in frataxin gene expression may be attributable from either the silencing of transcription of the frataxin gene because of epigenetic modifications in the chromosomal entity or from the inability of splicing the expanded GAA repeats in the first intron of the pre-mRNA as seen in bacteria and human cells or both. The expansion of intronic trinucleotide repeat GAA results in Friedreich's ataxia. [Wiki] Protein function: Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+), the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization, however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1. [The UniProt Consortium]
Schlagworte: Anti-FXN, Anti-FRDA, EC=1.16.3.1, Frataxin Antibody / FXN
Hersteller: NSJ Bioreagents
Hersteller-Nr: V3997SAF

Eigenschaften

Anwendung: IHC (paraffin)
Antikörper-Typ: Monoclonal
Klon: FDAX-1
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: Amino acids 57-210 from the human protein
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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