Anti-FOXM1 (Forkhead Box Protein M1, Forkhead-related Protein FKHL16, Hepatocyte Nuclear Factor 3 Fo

Anti-FOXM1 (Forkhead Box Protein M1, Forkhead-related Protein FKHL16, Hepatocyte Nuclear Factor 3 Fo
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
F9048-25D.20 20 µl - -

3 - 19 Werktage*

462,00 €
F9048-25D.100 100 µl - -

3 - 19 Werktage*

834,00 €
 
Forkhead box M1 (FoxM1) is a forkhead box family transcription factor that regulates a number of... mehr
Produktinformationen "Anti-FOXM1 (Forkhead Box Protein M1, Forkhead-related Protein FKHL16, Hepatocyte Nuclear Factor 3 Fo"
Forkhead box M1 (FoxM1) is a forkhead box family transcription factor that regulates a number of genes throughout the cell cycle to help control DNA replication, mitosis and cell proliferation. FoxM1 expression increases during G1 and S and reaches maximum levels in G2/M (1-3). Nuclear translocation occurs just before entry into G2/M and is associated with FoxM1 phosphorylation (4). Phosphorylation of FoxM1 by MAPK (Ser331 Ser704), Cyclin/ Cdk (Thr600, Thr611, Thr672), Plk1 (Ser715, Ser724), and Chk2 (Ser376) stabilizes and activates FoxM1 (4-7). Forkhead box M1 is expressed in all embryonic tissues but is restricted to proliferating tissues in adults (8). Recent studies have shown that FoxM1 expression is negatively regulated by p53 (9,10). Upregulation of FoxM1 is associated with many human cancers, including prostate, breast, lung, ovary, colon, pancreas, stomach, bladder, liver, and kidney, and may be associated with p53 mutations in some tumors (10,11). As a result, FoxM1 inhibitors have become a topic of interest for potential cancer therapy (12). Applications: Suitable for use in Immunofluorescence and Western Blot. Other applications not tested. Recommended Dilution: Immunofluorescence (IF-IC): 1:100, Western Blot: 1:1000, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Schlagworte: Anti-Forkhead box protein M1, Anti-M-phase phosphoprotein 2, Anti-HNF-3/fork-head homolog 11, Anti-Transcription factor Trident, Anti-Forkhead-related protein FKHL16, Anti-MPM-2 reactive phosphoprotein 2, Anti-Winged-helix factor from INS-1 cells
Hersteller: United States Biological
Hersteller-Nr: F9048-25D

Eigenschaften

Anwendung: IF, WB
Antikörper-Typ: Monoclonal
Klon: 11C1033(D12D5)
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Recombinant protein specific to the amino terminus of human FoxM1.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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