Anti-FNTB, NT (Protein Farnesyltransferase Subunit beta, FTase-beta, CAAX Farnesyltransferase Subuni

Anti-FNTB, NT (Protein Farnesyltransferase Subunit beta, FTase-beta, CAAX Farnesyltransferase Subuni
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
F0019-58X3-FITC.200 200 µl - -

1 - 19 Werktage

696,00 €
 
Eukaryotic cells contain 3 different types of prenyltransferases that attach either a farnesyl... mehr
Produktinformationen "Anti-FNTB, NT (Protein Farnesyltransferase Subunit beta, FTase-beta, CAAX Farnesyltransferase Subuni"
Eukaryotic cells contain 3 different types of prenyltransferases that attach either a farnesyl group (15 carbons) or a geranylgeranyl group (20 carbons) in thioether linkage to C-terminal cysteine residues in a variety of proteins. These posttranslational modifications provide a mechanism for membrane localization of proteins that lack a transmembrane domain. CAAX farnesyltransferase (FTase) attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This enzyme has the ability to farnesylate peptides as short as 4 residues in length that conform to the CAAX consensus sequence. The gene for the beta subunit of CAAX farnesyltransferase (FNTB) has been pinpointed to 14q23-q24 by Southern blot hybridization and PCR analyses of panels of human/Chinese hamster somatic cell hybrid lines and by fluorescence chromosomal in situ hybridization. Applications: Suitable for use in FLISA, Western Blot, and Immunohistochemistry. Other applications not tested. Recommended Dilution: FLISA: 1:1,000, Western Blot: 1:100-1:500, Immunohistochemistry: 1:50-1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Schlagworte: Anti-FNTB, Anti-FTase-beta, EC=2.5.1.58, Anti-CAAX farnesyltransferase subunit beta, Anti-Protein farnesyltransferase subunit beta, Anti-Ras proteins prenyltransferase subunit beta
Hersteller: United States Biological
Hersteller-Nr: F0019-58X3-FITC

Eigenschaften

Anwendung: FLISA, IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: FITC
Wirt: Rabbit
Reaktivität: Human
Immunogen: Synthetic peptide selected from the N-terminal region of human FNTB (KLH).
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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