Anti-FLT1, clone CL0344

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-AMAb90703.25 25 µl -

7 - 10 Werktage*

240,00 €
ATA-AMAb90703.100 100 µl -

7 - 10 Werktage*

358,00 €
 
Protein function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB... mehr
Produktinformationen "Anti-FLT1, clone CL0344"
Protein function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (Ref.11). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity, may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). [The UniProt Consortium] Validated by orthogonal and standard strategies. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 80% and to rat: 82%. Epitope specificity: EPQITWFKNN.
Schlagworte: Anti-FLT, Anti-FLT1, Anti-FLT-1, Anti-VEGFR-1, EC=2.7.10.1, Anti-Fms-like tyrosine kinase 1, Anti-Tyrosine-protein kinase FRT, Anti-Tyrosine-protein kinase receptor FLT, Anti-Vascular permeability factor receptor
Hersteller: Atlas Antibodies
Hersteller-Nr: AMAb90703

Eigenschaften

Anwendung: IHC
Antikörper-Typ: Monoclonal
Klon: CL0344
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: LNLTIMNVSL QDSGTYACRA RNVYTGEEIL QKKEITIRDQ EAPYLLRNLS DHTVAISSST TLDCHANGVP EPQITWFKNN HKIQQEPGII LGPGSSTLFI ERVTEEDEGV YHCKATNQKG S (ATA-APrEST93422)

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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