Anti-FKBP4

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-61037.60 60 µl -

7 - 16 Werktage*

198,00 €
E-AB-61037.120 120 µl -

7 - 16 Werktage*

317,00 €
E-AB-61037.200 200 µl -

7 - 16 Werktage*

525,00 €
 
The protein encoded by this gene is a member of the immunophilin protein family, which play a... mehr
Produktinformationen "Anti-FKBP4"
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-med Protein function: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. [The UniProt Consortium]
Schlagworte: Anti-FKBP4, Anti-FKBP52, EC=5.2.1.8, FKBP4 Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-61037

Eigenschaften

Anwendung: WB, IHC, IF, IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse
Immunogen: Recombinant protein of human FKBP4

Handhabung & Sicherheit

Lagerung: -20°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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