Anti-Fibronectin receptor/ VLA-5, clone NKI-SAM1 (Monoclonal) [Mouse]

Anti-Fibronectin receptor/ VLA-5, clone NKI-SAM1 (Monoclonal) [Mouse]
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
MON-MON1034 1 ml - -

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174,00 €
 
MON1034 recognizes a 150/130 kD receptor for fibronectin, (VLA-alpha-5 protein from the integrin... mehr
Produktinformationen "Anti-Fibronectin receptor/ VLA-5, clone NKI-SAM1 (Monoclonal) [Mouse]"
MON1034 recognizes a 150/130 kD receptor for fibronectin, (VLA-alpha-5 protein from the integrin superfamily of antigens). The antibody reacts with platelets, lymphocytes, monocytes and most cell lines including K562 and U937. Protein function: Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). [The UniProt Consortium]
Schlagworte: Anti-FNRA, Mouse anti-Fibronectin receptor/ VLA-5, clone NKI-SAM1 (Monoclonal)
Hersteller: MONOSAN
Hersteller-Nr: MON1034

Eigenschaften

Anwendung: IHC
Antikörper-Typ: Monoclonal
Klon: NKI-SAM1
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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