Anti-FHIT

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-60247.60 60 µl -

7 - 16 Werktage*

198,00 €
E-AB-60247.120 120 µl -

7 - 16 Werktage*

317,00 €
E-AB-60247.200 200 µl -

7 - 16 Werktage*

525,00 €
 
This gene, a member of the histidine triad gene family, encodes a diadenosine... mehr
Produktinformationen "Anti-FHIT"
This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. Protein function: Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low- affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor. [The UniProt Consortium]
Schlagworte: Anti-FHIT, Anti-AP3Aase, EC=3.6.1.29, Anti-AP3A hydrolase, Anti-Dinucleosidetriphosphatase, Anti-Bis(5'-adenosyl)-triphosphatase, Anti-Fragile histidine triad protein, Anti-Diadenosine 5',5'''-P1,P3-triphosphate hydrolase, FHIT Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-60247

Eigenschaften

Anwendung: WB, IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: Recombinant protein of human FHIT

Handhabung & Sicherheit

Lagerung: -20°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-FHIT"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen