Anti-FAS

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-F51184-0.08ML 80 µl - -

3 - 10 Werktage*

326,00 €
NSJ-F51184-0.4ML 400 µl - -

3 - 10 Werktage*

702,00 €
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. FAS is a member of the TNF-receptor superfamily. This... mehr
Produktinformationen "Anti-FAS"
In 1X PBS, pH 7.4, with 0.09% sodium azide. FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Protein function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). [The UniProt Consortium]
Schlagworte: Anti-FAS, Anti-APT1, Anti-CD95, Anti-Apo-1 antigen, Anti-FASLG receptor, Anti-Apoptosis-mediating surface antigen FAS, Anti-Tumor necrosis factor receptor superfamily member 6, FAS Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: F51184

Eigenschaften

Anwendung: WB, IF, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: A portion of amino acids 185-211 from the human protein was used as the immunogen for this FAS antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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