Anti-FADD (Fas-Associated Death Domain Protein, MORT1)

Anti-FADD (Fas-Associated Death Domain Protein, MORT1)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
F0019-51F.100 100 µl - -

3 - 19 Werktage*

456,00 €
 
Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter... mehr
Produktinformationen "Anti-FADD (Fas-Associated Death Domain Protein, MORT1)"
Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1beta-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation. Applications: Suitable for use in ELISA, Western Blotting. Other applications not tested. Recommended Dilution: Western Blotting: 1:500-1:1000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Hybridoma: Mouse FO myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human FADD protein. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Hersteller: United States Biological
Hersteller-Nr: F0019-51F

Eigenschaften

Anwendung: ELISA, WB
Antikörper-Typ: Monoclonal
Klon: 9A210
Konjugat: No
Wirt: Mouse
Reaktivität: Human
Immunogen: Recombinant human FADD (1-208aa) purified from E. coli
Reinheit: Purified
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C (-20°C Glycerol)
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier folgen Informationen zur Produktreferenz. mehr
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-FADD (Fas-Associated Death Domain Protein, MORT1)"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen