Anti-Estrogen Receptor beta, clone ERb455

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-V2115SAF-100UG 100 µg - -

3 - 10 Werktage*

752,00 €
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. Estrogen receptors (ER) are members of the... mehr
Produktinformationen "Anti-Estrogen Receptor beta, clone ERb455"
1 mg/ml in sterile PBS, BSA free, sodium azide free. Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including alpha and beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER alpha and beta are differentially activated by various ligands. Ligand interaction triggers a cascade of events, including dissociation from heat shock proteins, recepter dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER alpha and beta may be regulated by distinct mechanisms even though they share many functional characteristics. Protein function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. [The UniProt Consortium]
Schlagworte: Anti-ESR2, Anti-ESTRB, Anti-ER-beta, Anti-Estrogen receptor beta, Anti-Nuclear receptor subfamily 3 group A member 2, Estrogen Receptor beta Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: V2115SAF

Eigenschaften

Anwendung: WB, IHC, FC, IF
Antikörper-Typ: Monoclonal
Klon: ERb455
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human, monkey, mouse, rat, swine, horse, sheep
Immunogen: The C-terminus fragment of recombinant human Estrogen Receptor beta protein was used as the immunogen for this antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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