Anti-ERBB3 (HER3)

Anti-ERBB3 (HER3)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-R30980 100 µg - -

3 - 10 Werktage*

755,00 €
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. V-erb-b2 avian erythroblastic leukemia... mehr
Produktinformationen "Anti-ERBB3 (HER3)"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3, also known as HER3, is an enzyme that in humans is encoded by the ERBB3 gene. This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. By in situ hybridization, Kraus et al.(1989) mapped the gene to chromosome 12q13. Carraway et al.(1994) demonstrated that ERBB3 is a receptor for Heregulin and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself. Most notably, EGFR and ERBB2 became markedly more promiscuous as the threshold was lowered, whereas ERBB3 did not. Engelman et al.(2007) found that amplification of MET caused gefitinib resistance by driving ERBB3-dependent activation of phosphoinositide 3-kinase, a pathway though to be specific to EGFR/ERBB family receptors. Protein function: Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5. [The UniProt Consortium]
Schlagworte: Anti-HER3, Anti-ERBB3, EC=2.7.10.1, Anti-Proto-oncogene-like protein c-ErbB-3, Anti-Receptor tyrosine-protein kinase erbB-3, Anti-Tyrosine kinase-type cell surface receptor HER3, ERBB3 Antibody (HER3)
Hersteller: NSJ Bioreagents
Hersteller-Nr: R30980

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: An amino acid sequence from the N-terminus of human ERBB3/HER3 (DWRDIVRDRDAEIVVKDNGR) was used as the immunogen for this ERBB3 antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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