Anti-ERBB2

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA001383.25 25 µl -

7 - 10 Werktage*

240,00 €
ATA-HPA001383.100 100 µl -

7 - 10 Werktage*

358,00 €
 
Protein function: Protein tyrosine kinase that is part of several cell surface receptor... mehr
Produktinformationen "Anti-ERBB2"
Protein function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 82% and to rat: 81%
Schlagworte: Anti-HER2, Anti-CD340, Anti-ERBB2, Anti-MLN 19, Anti-p185erbB2, EC=2.7.10.1, Anti-Proto-oncogene Neu, Anti-Proto-oncogene c-ErbB-2, Anti-Metastatic lymph node gene 19 protein, Anti-Receptor tyrosine-protein kinase erbB-2
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA001383

Eigenschaften

Anwendung: WB, IHC, ICC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: LPSETDGYVA PLTCSPQPEY VNQPDVRPQP PSPREGPLPA ARPAGATLER PKTLSPGKNG VVKDVFAFGG AVENPEYLTP QGGAAPQPHP PPAFSPAFDN LYYWDQDPPE RGAPPSTFKG TPTA (ATA-APrEST79717)

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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