Anti-EPHA10 (Ephrin Type-A Receptor 10)

EphA10 is a member of the Eph family of receptor tyrosine kinases that are activated by binding members of the Ephrin ligand family. EphA10 preferentially binds Ephrin-A3, -A4 and -A5. EphA10 mRNA expression appears limited to the testis, unlike most Ephs that are expressed in developing and adult neural tissue. Human EphA10 extracellular domain (ECD) shares 95-88aa identity with mouse and rat EphA10, respectively. Of three alternately spliced isoforms, one is truncated within the ECD and another within the cytoplasmic domain. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry: 8-25ug/ml using immersion fixed paraffin-embedded sections of human brain (cortex), Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.