Anti-Enhancer-binding protein beta

Anti-Enhancer-binding protein beta
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
MM-0233-P 100 µg - -

3 - 8 Werktage*

722,00 €
 
Protein function: Important transcription factor regulating the expression of genes involved in... mehr
Produktinformationen "Anti-Enhancer-binding protein beta"
Protein function: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing. During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development. Restricts osteoclastogenesis. [The UniProt Consortium]
Schlagworte: Anti-LAP, Anti-LIP, Anti-TCF5, Anti-TCF-5, Anti-PP9092, Anti-C/EBP beta, Anti-Nuclear factor NF-IL6, Anti-Transcription factor 5, Anti-Liver activator protein, Anti-Liver-enriched inhibitory protein, Anti-CCAAT/enhancer-binding protein beta
Hersteller: MediMabs
Hersteller-Nr: MM-0233-P

Eigenschaften

Anwendung: WB, IF
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Chicken
Spezies-Reaktivität: human, mouse, rat, swine, bovine

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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