Anti-eIF4G (Ab-1232)

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-35-1729-50 50 µl -

3 - 11 Werktage*

574,00 €
 
eIF4F is a multi-subunit complex, the composition of which varies with external and internal... mehr
Produktinformationen "Anti-eIF4G (Ab-1232)"
eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E, insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with MIF4GD. Interacts with rotavirus A NSP3, in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis De Gregorio, E. et al. (1998) RNA 4, 828-836. Ohlmann, T. et al. (1996) EMBO J. 15, 1371-1382. Borman, A.M. and Kean, K.M. (1997) Virology 237, 129-136. Gradi, A. et al. (1998) Mol Cell Biol 18, 334-42. Protein function: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress- induced ATF4 mRNA translation (PubMed:29062139). [The UniProt Consortium]
Schlagworte: Anti-p220, Anti-EIF4F, Anti-EIF4G1, Anti-eIF-4G1, Anti-eIF-4G 1, Anti-eIF-4-gamma 1, Anti-Eukaryotic translation initiation factor 4 gamma 1, Polyclonal Antibody to eIF4G (Ab-1232)
Hersteller: Abeomics
Hersteller-Nr: 35-1729-50

Eigenschaften

Anwendung: WB, IHC, IF
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Peptide sequence around aa.1230~1234 (P-V-S-P-L) derived from Human eIF4G.
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-eIF4G (Ab-1232)"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen