Anti-EIF4ENIF1

Anti-EIF4ENIF1
Anti-EIF4ENIF1
   
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA001619.25 25 µl -

Fragen Sie uns nach der Lieferzeit

156,00 €
ATA-HPA001619.100 100 µl -

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363,00 €
 
Protein function: EIF4E-binding protein that regulates translation and stability of mRNAs in... mehr
Produktinformationen "Anti-EIF4ENIF1"
Protein function: EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis. Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P- bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 93% and to rat: 95%
Schlagworte: Anti-4E-T, Anti-eIF4E transporter, Anti-Eukaryotic translation initiation factor 4E transporter, Anti-Eukaryotic translation initiation factor 4E nuclear import factor 1
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA001619

Eigenschaften

Anwendung: ICC, IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: FAPIPLEDHA ENKVDILEML QKAKVDLKPL LSSLSANKEK LKESSHSGVV LSVEEVEAGL KGLKVDQQVK NSTPFMAEHL EETLSAVTNN RQLKKDGDMT AFNKLVSTMK ASGTLPSQPK VSRNLESHLM SPAEI (ATA-APrEST73539)

Datenbank Information

KEGG ID : K18728 | Passende Produkte
UniProt ID : Q9NRA8 | Passende Produkte
Gene ID : GeneID 56478 | Passende Produkte
Protein Atlas Nr. : ENSG00000184708

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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