Anti-eIF3D/EIF3S7

Anti-eIF3D/EIF3S7
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A301-759A-T 20 µl (2 blots) -

3 - 9 Werktage

125,00 €
A301-759A-M 100 µl (10 blots) -

3 - 9 Werktage

299,00 €
A301-759A 100 µl (20 µg) -

3 - 9 Werktage

443,00 €
 
Protein function: mRNA cap-binding component of the eukaryotic translation initiation factor 3... mehr
Produktinformationen "Anti-eIF3D/EIF3S7"
Protein function: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815). [The UniProt Consortium]
Schlagworte: Anti-eIF3d, Anti-eIF3 p66, Anti-eIF-3-zeta, Anti-Eukaryotic translation initiation factor 3 subunit D, Anti-Eukaryotic translation initiation factor 3 subunit 7
Hersteller: Bethyl Laboratories
Hersteller-Nr: A301-759A-T

Eigenschaften

Anwendung: WB, IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human (Erwartet: Mouse, Rat, Bovine, Orangutan)
Immunogen: synthetic peptide. The epitope recognized by A301-759A-T maps to a region between residue 200 and 250 of human eukaryotic translation initiation factor 3, subunit D (eukaryotic translation initiation factor 3, subunit 7) using the numbering given in entry NP_003744.1 (GeneID 8664).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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