Anti-EIF3D

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-63830.60 60 µl -

7 - 16 Werktage*

198,00 €
E-AB-63830.120 120 µl -

7 - 16 Werktage*

317,00 €
E-AB-63830.200 200 µl -

7 - 16 Werktage*

525,00 €
 
Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein... mehr
Produktinformationen "Anti-EIF3D"
Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. Protein function: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815). [The UniProt Consortium]
Schlagworte: Anti-eIF3d, Anti-eIF3 p66, Anti-eIF-3-zeta, Anti-Eukaryotic translation initiation factor 3 subunit D, Anti-Eukaryotic translation initiation factor 3 subunit 7, EIF3D Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-63830

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: Recombinant protein of human EIF3D

Handhabung & Sicherheit

Lagerung: -20°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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