Anti-EIF2AK3, CT (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3, PRKR-like Endoplasmic R

Anti-EIF2AK3, CT (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3, PRKR-like Endoplasmic R
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E8949-17A-APC.200 200 µl - -

1 - 19 Werktage

696,00 €
 
PERK, a member of the GCN2 subfamily of Ser/Thr protein kinases, phosphorylates the alpha subunit... mehr
Produktinformationen "Anti-EIF2AK3, CT (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3, PRKR-like Endoplasmic R"
PERK, a member of the GCN2 subfamily of Ser/Thr protein kinases, phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It likely serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1 Perturbation in protein folding in the endoplasmic reticulum (ER) promotes reversible dissociation from HSPA5/BIP and oligomerization, resulting in transautophosphorylation and kinase activity induction Expression of this Type I membrane protein is ubiquitous, with highest levels seen in secretory tissues. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities. Applications: Suitable for use in FLISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: FLISA: 1:1,000, Immunohistochemistry: 1:50-1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Schlagworte: Anti-PEK, Anti-HsPEK, Anti-EIF2AK3, EC=2.7.11.1, Anti-Pancreatic eIF2-alpha kinase, Anti-PRKR-like endoplasmic reticulum kinase, Anti-Eukaryotic translation initiation factor 2-alpha kinase 3
Hersteller: United States Biological
Hersteller-Nr: E8949-17A-APC

Eigenschaften

Anwendung: FLISA, IHC
Antikörper-Typ: Polyclonal
Konjugat: APC
Wirt: Rabbit
Reaktivität: Human
Immunogen: Synthetic peptide selected from the C-terminal region of human PERK (KLH).
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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