Anti-EGF Receptor, clone 688CT33.1.3

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-F40405-0.08ML 80 µl - -

3 - 10 Werktage*

326,00 €
NSJ-F40405-0.4ML 400 µl - -

3 - 10 Werktage*

702,00 €
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. The protein encoded by this gene is a transmembrane... mehr
Produktinformationen "Anti-EGF Receptor, clone 688CT33.1.3"
In 1X PBS, pH 7.4, with 0.09% sodium azide. The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]
Schlagworte: Anti-EGFR, Anti-ERBB, EC=2.7.10.1, Anti-Proto-oncogene c-ErbB-1, Anti-Epidermal growth factor receptor, Anti-Receptor tyrosine-protein kinase erbB-1, EGF Receptor Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: F40405

Eigenschaften

Anwendung: WB, IHC, ELISA
Antikörper-Typ: Monoclonal
Klon: 688CT33.1.3
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: A portion of amino acids 1163-1191 from the human protein was used as the immunogen for this EGF Receptor antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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