Anti-EFNA1

Anti-EFNA1
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-14062.20 20 µl -

7 - 16 Werktage*

71,00 €
E-AB-14062.60 60 µl -

7 - 16 Werktage*

143,00 €
E-AB-14062.120 120 µl -

7 - 16 Werktage*

238,00 €
E-AB-14062.200 200 µl -

7 - 16 Werktage*

396,00 €
 
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors... mehr
Produktinformationen "Anti-EFNA1"
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. Protein function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. [The UniProt Consortium]
Schlagworte: Anti-EFNA1, Anti-EPLG1, EFNA1 Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-14062

Eigenschaften

Anwendung: IHC, ELISA
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: Recombinant protein of human EFNA1
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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